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The Pfizer / BioNTech COVID-19 vaccine was developed by BioNTech (a German biotechnology company) in cooperation with Pfizer (an American pharmaceutical corporation).
It was the first COVID-19 vaccine to be approved by the UK’s Medicines and Healthcare products Regulatory Agency. The decision was made with advice from the Commission on Human Medicines (CHM), the government’s independent expert scientific advisory body.
2 December 2020
How does the Pfizer / BioNTech vaccine work in the body when taken?
The jabs are known as a messenger RNA (mRNA) vaccine. It uses synthetically produced genetic material called mRNA, which encodes the instructions to produce the SARS-CoV-2 (COVID-19) spike protein (the part of the virus that allows it to enter human cells).
The injection inserts this mRNA into the body. This then enters cells, which read the genetic code and start producing the virus protein – thus triggering a response by the immune system and coaching it to fight a future infection.
The mRNA molecule is not injected directly into the body, but is wrapped in oily bubbles made of lipid nanoparticles, to prevent our natural enzymes from breaking it down.
The jab uses mRNA produced in the lab by a template DNA, and doesn’t use a virus, unlike conventional vaccines which are produced using weakened forms of the virus. This can make the rate at which it can be produced or modified dramatically accelerated.
What are the ingredients of the Pfizer / BioNTech vaccine?
This vaccine contains polyethylene glycol/macrogol (PEG) as part of ALC-0159.
دوسرے اجزاء یہ ہیں:
Potassium dihydrogen phosphate
Cholesterol
سوکروز
سوڈیم کلورائد
Potassium chloride
Disodium hydrogen phosphate dihydrate
1,2-Distearoyl-sn-glycero-3-phosphocholine
ALC-0159 = 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide
ALC-0315 = (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate)
You should not take the vaccine if you have ever had a severe allergic reaction to any of the active substances or any of the other ingredients.
How is the Pfizer / BioNTech vaccine administered?
The Pfizer / BioNTech vaccine is only being administered to people in a safe health care environment with facilities to treat allergic reactions if they do occur. Do not take the vaccine from anyone else. If offered by anyone, and you are in doubt, contact your GP.
This vaccine is given after dilution as an injection of 0.3 mL into a muscle of your upper arm.
You will receive 2 injections (of the same vaccine), given at least 21 days apart.
Protection against COVID-19 disease may not be maximally effective until at least 7 days after the second dose.
ویکسین کے ہر انجیکشن کے دوران اور اس کے بعد ، آپ کا ڈاکٹر ، فارماسسٹ یا نرس الرجی رد عمل کی علامتوں کی نگرانی کے ل around آپ کو 15 منٹ کے لئے نگرانی کریں گے۔
Are there any possible risks and/or side effects of the Pfizer / BioNTech vaccine?
ادویہ میں کچھ بھی خطرے کے بغیر نہیں آتا ہے - یہاں تک کہ ہم بغیر سوچے سمجھے کچھ لیتے ہیں جیسے پیراسیٹامول ، خطرہ لاحق ہے۔
Like all vaccines, the Pfizer / BioNTech vaccine can cause side effects, although not everybody gets them.
Most side effects are mild or moderate and go away within a few days of appearing. If side effects such as pain and/or fever are troublesome, they can be treated by medicines for pain and fever such as paracetamol.
ضمنی اثرات میں شامل ہوسکتے ہیں:
بہت عام (10 افراد میں 1 سے زیادہ کو متاثر کرسکتا ہے)
سر درد
Muscle pain, joint pain, pain at the injection site
تھکاوٹ
بخار
Chills
عام (10 افراد میں 1 تک 1 تک متاثر ہوسکتی ہے)
Swelling at the injection site
Redness at the injection site
متلی
غیر معمولی (100 میں سے 1 افراد تک متاثر ہوسکتا ہے)
Feeling unwell
بڑھا ہوا لمف نوڈس
Rare (may affect up to 1 in 1000 people)
Temporary one-sided facial drooping (Bell’s palsy)
Frequency unknown
Severe allergic reactions (anaphylaxis)
انتباہات اور احتیاطی تدابیر
آپ کو یہ ویکسین دینے سے پہلے اپنے ڈاکٹر ، فارماسسٹ یا نرس سے بات کریں اگر آپ:
Ever had a severe allergic reaction or breathing problems after any other vaccine injection or after you were the vaccine in the past.
A severe illness with high fever. However, a mild fever or upper airway infection, like a cold, are not reasons to delay vaccination.
A weakened immune system, such as due to HIV infection, or are on a medicine that affects your immune system.
A bleeding problem, bruise easily or use a medicine to inhibit blood clotting.
اگر ویکسین نہ لیں
you are allergic to the active substance or any of the other ingredients of this vaccine
Signs of an allergic reaction may include itchy skin rash, shortness of breath and swelling of the face or tongue. Contact your doctor or healthcare professional immediately or go to the nearest hospital emergency room right away if you have an allergic reaction. It can be life-threatening.
جیسا کہ کسی بھی ویکسین کی طرح ، یہ ویکسین ان تمام لوگوں کی پوری طرح حفاظت نہیں کرسکتی ہے جو اسے وصول کرتے ہیں۔
کمزور مدافعتی نظام والے افراد میں یا فی الحال کوئی ایسا اعداد و شمار دستیاب نہیں ہیں جو دائمی علاج کر رہے ہیں جو مدافعتی ردعمل کو دباتا یا روکتا ہے۔